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Showing posts with label Melbourne. Show all posts
Showing posts with label Melbourne. Show all posts

08 December 2014

CEOs of leading cancer organisations stand together in the fight to reduce tobacco-related death across the world



Cancer Research UK, the Union for International Cancer Control, the US National Cancer Institute and Cancer Council Australia, today formally united to further research into evidence-based tobacco control, to reduce the millions of tobacco-related deaths that occur across the world each year.

Cancer Research UK today pledged £5 million to establish, with its cancer fighting partners, the International Consortium for Action and Research on Tobacco, and fund tobacco control research programmes in low-and-middle income countries (LMICs), where the impact of tobacco-related cancer is greatest.

Cancer Research UK Chief Executive Officer Harpal Kumar comments: “Tobacco consumption is a burning platform that requires an urgent global solution. Governments around the world have committed to reduce tobacco use by 30 per cent by 2025. This won't be achieved by words alone. We have to reduce the huge number of lives affected by tobacco and we hope that the announcement of this global consortium, backed up by this initial investment pledge, will help expand tobacco control research in the countries which need it most. We will generate locally relevant evidence that will be capable of being implemented rapidly. If we act together, we could save 200 million of the one billion tobacco deaths that we will otherwise see this century.”

Tobacco remains the world’s single most preventable cause of death and disease. Significantly:
·         Tobacco kills six million people each year worldwide, and is responsible for one in three cancer deaths
·         By 2030, over 80% of tobacco-related mortality will be in low LMICs
·         Tobacco will kill about one billion people in the 21st century, if current trends continue

“Millions of people are dying throughout the world each year due to something that is entirely preventable. The global cancer community must unite to reduce tobacco use. By joining forces we will accelerate progress in tobacco control and ultimately save lives that would otherwise be needlessly lost. Through the International Consortium for Action and Research on Tobacco we commit to mobilise our combined knowledge and resources in this fight”, said Cary Adams, UICC Chief Executive Officer.

Whilst a large body of tobacco control research has been generated in high-income countries, there is an acute need for high-quality, locally-relevant research that informs policy and addresses the varying social, economic, cultural and political situations in LMICs. This is the key priority of the International Consortium for Action and Research on Tobacco.

“Australia has led the way in innovative tobacco control policies. We are proud to be helping found the International Consortium for Action and Research on Tobacco, and to share our knowledge and experiences to further advance tobacco control worldwide”, noted Professor Ian Olver, Chief Executive Officer, Cancer Council Australia.

15 November 2014

Study highlights women’s distress at lack of interest in sex

A qualitative study from a team of researchers at Monash University (Melbourne) has sought to understand the personal impact of loss of sexual interest on women and the expectations of women seeking treatment for their problem. This is the first study to consider the real-life situation of women seeking treatment at a clinic; previous studies have actively sought out women with sexual problems, which may change the expectations and experiences of the patients. This work is published in the December edition of the peer-reviewed journal Climacteric*.
Loss of sexual interest is the most commonly reported sexual problem amongst women. Although researchers have identified that loss of interest in sex can be very concerning for women, there has been little understanding as to what motivates women to seek help for this problem. There is also little known about women’s expectations of treatment for female sexual dysfunction.
The team interviewed 17 women who had been referred to the Cabrini Medical Centre (Melbourne, Australia) for specialist assessment and possible treatment.  In depth face-to-face interviews took place prior to the medical consultation, in which women were asked to talk about their sexual worries and the reasons for attending the clinic. Four major themes emerged during the course of the interviews.
1 Personal psychological distress: these feelings manifested themselves in low self-esteem, feelings of guilt, sadness, worthlessness, inadequacy, frustration, disappointment and embarrassment:
·         ‘I think a feeling of guilt from my point of view and from my husband probably a feeling of not being attractive to me. A feeling of not being adequate maybe’ (Olivia, aged 43).
·         Older participants also reported psychological distress. Justine, aged 70, stated: ‘I just do not feel inclined to have sex. I want to approach my husband, to be physical. There is nothing there. I just don’t feel anything at all. You know it has been for a few years now and I just don’t think that’s normal because I am not that old. This is disappointing that I do not like to be touched. ’
2: Concern about the adverse effect of lack of sexual interest on the relationship with their sexual partner Although most women appreciated their partner ’s support, they were concerned about the negative effects of their sexual problems on intimacy and cited this as a driving factor for seeking medical help:
·         Stella, aged 47 described: ‘Physically I don’t really feel like I need to be sexually active. I do get concerned about the future and whether it is going to affect the relationship with my husband. ’
·         Emma, aged 51 stated: ‘It’s not like our marriage is in trouble because of it, but it is definitely something that we both would like to enjoy and my husband would like more of. It is important for any marriage and relationship. You still need to have that regardless of how long we’re together whether it’s 10, 20, 30 years. I guess it’s always the thought of hearing other people having regular sex and you say “what’s wrong with me?”. ’
 
Theme 3: A belief in a relationship between lack of sexual interest and ‘hormone deficiency ’
Many women spoke of a ‘lack of hormones in their bodies ’:
·         Clara, aged 62 said ‘… But you are not dead yet, you are still functioning, your body still functions, but when we are menopausal our levels go down and of course you don’t feel like sex.
 
Theme 4: An expectation of treatment outcomes, which included positive physical and sexual changes
Many women viewed hormonal treatment as a ‘magic bullet’. Postmenopausal women were eager to receive menopausal hormone therapy and testosterone. Women hoped these would benefit them physically and sexually, that they would have more energy, look younger and fitter and be healthier. They anticipated increased spontaneous sex drive, arousal, orgasm and an enjoyable sex life:
·         Adele, aged 53, said ‘ … I want some energy. I feel I am a young, fit, healthy, happy woman. I am blessed, but I just would like to not feel like I’m 80 years old sometimes. I don’t recover from exercise anymore. I am quite exhausted and I fall asleep all the time. I like to feel more energetic, to not be asleep at 9 o’ clock at night every night. That would be nice and probably to feel more spontaneous’.
 
3-4 months after treatment, 10 of the women were again interviewed. Treatment with vaginal estrogen alone or MHT (Menopausal Hormone Therapy) alleviated the symptoms of concern and was associated with improved sexual wellbeing. Four women who were treated with testosterone therapy, in addition to MHT, all reported a benefit of treatment.
 
·         Justine, 70 years, said: ‘Before I did not like to be touched and that is improved after treatment. I feel ok. I am feeling better in myself.
·         Alice, a breast cancer survivor, reported only partial symptom relief with vaginal estrogen therapy said: ‘ … there is (still) some pain, but intercourse is not impossible’
 
Research leader, Professor Susan Davis said.
 
“It is important to understand that this is a qualitative study, not a clinical trial. Studies such as this help us get to the core of what women who want treatment are experiencing and inform us about what we should be looking at, and which questions to ask in a clinical trial.  A huge number of women are affected by sexual problems globally, but we don’t really know much about how it makes women feel and what they expect of treatment. The important feature about this study is that the participants didn’t respond to an ad to be in the study. These were simply women attending a practice seeking help for their problem.  This study shows that the women who are seeking help for sexual interest/arousal problems are profoundly affected by their problem.  Most of the women we interviewed were deeply concerned about intimacy and about the effect of lack of sexual interest on their relationship.  Often the distress many women feel because of this just isn’t understood”.

Commenting, Professor Camil Castelo-Branco (Chair of the Council of Affiliated Menopause Societies**, and Professor of Obstetrics and Gynecology at Barcelona University) said:
 
“This qualitative study examines the personal impact of loss of sexual interest on women, and also what were the expectations of those women who sought treatment for their sexual problems. But data from this qualitative study may give additional clues for health care providers.   If we could reproduce this work on a larger sample, we may be able to assign these patients into groups which would allow us to design specific therapies for sexual problems and better management of this condition: in other words, to give a more personalized management of sexual problems.

Health care providers should keep in mind that the women in this study have broken through considerable personal barriers in talking about their problems. Intimacy is difficult to talk about, and these women deserve our respect. We owe it to them, and to other women (and indeed men) suffering as a result of this problem, to help improve their quality of life”.

23 July 2010

Descubren la causa de la celiaquía


Científicos del Instituto de Investigación Médica Walter&Eliza Hall, en Melbourne (Australia) han descubierto tres compuestos clave en el gluten --una proteína que se encuentra en el trigo, centeno y cebada-- que son los causantes de la enfermedad celiaca, según los resultados de la investigación que publica en su último número la revista 'Science Translational Medicine'.

En este trastorno digestivo, el gluten provoca una reacción en el sistema inmune que daña la capa que recubre el intestino delgado dificultando su capacidad para absorber nutrientes y, si la enfermedad no se detecta, se puede provocar una severa desnutrición.

Actualmente no existen tratamientos para esta patología, por lo que la única solución es que los pacientes dejen de comer productos con gluten aunque, según los autores de esta investigación, el hallazgo podría conducir al desarrollo de nuevos tratamientos y métodos de diagnóstico.

"El Santo Grial de la investigación de la enfermedad celíaca ha sido identificar los componentes tóxicos del gluten", ha explicado a la BBC el doctor Bob Anderson, autor de la investigación, que ha durado nueve años y en la que han participado más de 200 pacientes de Melbourne y Oxford (Reino Unido).

Según explica Anderson, se pidió a los voluntarios que comieran pan de trigo y centeno, y cebada hervida. Seis días después se tomaron muestras de sangre de los pacientes para medir su respuesta inmune a miles de distintos componentes del gluten.

De este modo, las pruebas identificaron 90 péptidos que causaban algún tipo de reacción inmune, pero se encontró que tres de éstos eran particularmente tóxicos. Según el profesor Anderson "estos tres componentes están involucrados en la mayoría de las respuestas inmunes del gluten que se observan en las personas que sufren enfermedad celiaca".

--EL PRIMER PASO PARA UNA FUTURA VACUNA

El nuevo hallazgo ya está siendo utilizado por una compañía de biotecnología para desarrollar una inmunoterapia que permita insensibilizar a los pacientes celíacos a los efectos tóxicos del gluten, y consistiría en exponer al enfermo a pequeñas cantidades de los tres péptidos tóxicos.

La primera fase de los ensayos clínicos fue completada en junio pasado y se espera tener los resultados en los próximos meses. Sarah Sleet, presidenta ejecutiva de la organización Coeliac Uk, afirma que el hallazgo potencialmente podría conducir a una vacuna contra la enfermedad.

"Es una pieza importante en el rompecabezas, pero todavía se necesitan más investigaciones, así que no deberíamos esperar una solución práctica en los próximos años", explica a la BBC, en declaraciones recogidas por Europa Press.

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