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03 January 2012
Schizophrenia Diagnosis Associated With Progressive Brain Changes Among Adolescents
"Progressive loss of brain gray matter (GM) has been reported in childhood-onset schizophrenia; however, it is uncertain whether these changes are shared by pediatric patients with different psychoses," the authors write as background information in the study.
Celso Arango, M.D., Ph.D., of the Hospital General Universitario Gregorio Marañón, Madrid, Spain, and colleagues, examined the progression of brain changes in first-episode early-onset psychosis and the relationship to diagnosis and prognosis at two-year follow-up among patients at six child and adolescent psychiatric units in Spain. The authors performed magnetic resonance imaging (MRI) of the brain for 61 patients (25 diagnosed with schizophrenia, 16 with bipolar disorder and 20 with other psychoses) and 70 healthy control participants. MRI scans were conducted at study baseline and after two years of follow-up.
Compared with control patients, those diagnosed with schizophrenia showed greater gray matter volume loss in the frontal lobe during the two-year follow-up. Patients with schizophrenia also showed cerebrospinal fluid increase in the left frontal lobe. Additionally, changes for total brain gray matter and left parietal gray matter were significantly different in patients with schizophrenia compared with patients in the control group.
Among patients with schizophrenia, progressive brain volume changes in certain areas were related to markers of poorer prognosis, such as more weeks of hospitalization during follow-up and less improvement in negative symptoms. Greater left frontal gray matter volume loss was related to more weeks of hospitalization whereas severity of negative symptoms correlated with cerebrospinal fluid increase in patients with schizophrenia.
The authors did not find any significant changes in patients with bipolar disorder compared to control patients, and longitudinal brain changes in the control group were consistent with the expected pattern described for healthy adolescents.
"In conclusion, we found progression of gray matter volume loss after a two-year follow-up in patients who ended up with a diagnosis of schizophrenia but not bipolar disease compared with healthy controls," the authors write. "Some of these pathophysiologic processes seem to be markers of poorer prognosis. To develop therapeutic strategies to counteract these pathologic progressive brain changes, future studies should focus on their neurobiological underpinnings."
*Story Source:
The above story is reprinted from materials provided by JAMA and Archives Journals. e cited above
Un equipo español apunta que la pérdida de manganeso causa la osteoporosis
"El descenso de manganeso impide que se fije bien el calcio y, por tanto, los huesos se debilitan. Si el cuerpo humano con la edad pierde manganeso (que absorbe sobre todo del intestino delgado y el hígado) tendrá que obtenerlo del esqueleto, pues el mineral es necesario para varios órganos, entre ellos el cerebro. Lo que sucede es que al mismo tiempo que saca el manganeso extrae también calcio, que ya no vuelve a fijar bien y se elimina por la orina", explica a ELMUNDO.es Tomás Landete-Castillejos, coordinador del trabajo que se publica en la revista 'Frontiers of Bioscience'. De esta forma puede ir desarrollándose poco a poco la osteoporosis.
La teoría tiene que ser confirmada ahora con estudios y ensayos médicos, pero sus autores consideran, según han declarado a la Agencia SINC, que "puede dar un giro en una nueva dirección totalmente distinta a las consideradas hasta ahora en osteoporosis, al establecer que la pérdida de calcio puede ser la consecuencia pero no el origen". Si se valida la hipótesis, la terapia para combatir el trastorno también tendrá que cambiar, porque hasta ahora todos los tratamientos se orientan a potenciar los niveles de calcio.
El año en el que las cuernas de los ciervos se empezaron a romper hizo mucho frío. Esto provocó que las plantas redujeran sus concentraciones de manganeso, como respuesta al estrés y, por tanto, los animales obtuvieron menos cantidad de este mineral y sus cuernos pagaron las consecuencias de esta carencia.
"Un estudio en ratas de 1986 ya confirmó que una pérdida de manganeso daba huesos con menos calcio, pero no ha habido muchos más estudios en la misma línea", reconoce Landete-Castillejos.
-Vínculo con el Alzheimer y el Parkinson
La teoría de estos investigadores va aún más allá y sugieren que al desarrollarse la osteoporosis e ir agotándose el manganeso, esencial para el cerebro, podrían aparecer otros trastornos, como el Parkinson o el Alzheimer.
"Hemos tratado de buscar esta relación y vimos en el Hospital de Hellín (Albacete) que de un grupo de pacientes operados por osteoporosis, el 40% desarrolló algún tipo de problema cerebral, como el Alzheimer, mientras que los operados de osteoartritis (que es el desgaste del cartílago, no del hueso) ninguno desarrolló estos trastornos", señala el autor del estudio.
"De momento tenemos una hipótesis que es como un queso gruyère. Tiene una base sólida -la relación entre el manganeso y la debilidad de los huesos- y muchos agujeros que tendrán que ir rellenando los investigadores médicos. Ésa ya no es nuestra labor", argumenta el experto de la Universidad de Castilla-La Mancha.
No obstante, cree que la base es suficientemente sólida para profundizar en el tema e investigar a fondo, por las implicaciones médicas que puede tener.
**Publicado en "EL MUNDO"
Nowhere to Go, Patients Linger in Hospitals, at a High Cost
Yu Kang Fu was moved to a care center in Brooklyn last spring after spending over four years at New York Downtown Hospital.
As a result, hospitals are absorbing the bill for millions of dollars in unreimbursed expenses annually while the patients, trapped in bureaucratic limbo, are sometimes deprived of services that could be provided elsewhere at a small fraction of the cost.
“Many of those individuals no longer need that care, but because they have no resources and many have no family here, we, unfortunately, are caring for them in a much more expensive setting than necessary based on their clinical need,” said LaRay Brown, a senior vice president for the city’s Health and Hospitals Corporation. Under state law, public hospitals are not allowed to discharge patients to shelters or to the street.
Medicaid often pays for emergency care for illegal immigrants, but not for continuing care, and many hospitals in places with large concentrations of illegal immigrants, like Texas, California and Florida, face the quandary of where to send patients well enough to leave. Officials in New York City say they have many such patients who are draining money from the health system as the cost of keeping people in acute-care hospitals continues to escalate.
But even if Medicaid pays for some care, taxpayer dollars are ultimately being consumed by patients who could be cared for in nursing homes or other health facilities, and even at home if supportive services were available. Care for a patient languishing in a hospital can cost more than $100,000 a year, while care in a nursing home can cost $20,000 or less.
Patients fit to be discharged from hospitals but having no place to go typically remain more than five years, Ms. Brown said. She estimated that there were about 300 patients in such a predicament throughout the city, most in public hospitals or higher-priced skilled public nursing homes, though a smattering were in private hospitals.
One patient, a former hospital technician from Queens, has lived at the city’s Coler-Goldwater Specialty Hospital and Nursing Facility on Roosevelt Island for 13 years because the hospital has no place to send him, Ms. Brown said. The patient, who is in his mid-60s, has been there since an arterial disease cost him part of one leg below the knee and left him in a wheelchair. The city’s public health system declined to provide the names of any long-term patients or make them available for interviews, citing confidentiality laws.
Five years ago, Yu Kang Fu, 58, who lived in Flushing, Queens, and was a cook at a Chinese restaurant in New Jersey, was dropped off by his boss at New York Downtown Hospital, a private institution in Manhattan, complaining of a severe headache. Mr. Yu was admitted to the intensive-care unit with a stroke.
Within days, he was well enough for hospital personnel to begin planning for his release, but as an illegal immigrant (he had overstayed a work visa a decade ago), he was ineligible for health benefits. And no nursing home or rehabilitation center would take him. Neither would his son in China nor the Chinese government, although the hospital volunteered to fly him there at its expense.
Mr. Yu’s protracted hospital stay was first chronicled in an article in The New York Times in 2008 about the treatment of uninsured immigrants.
Mr. Yu remained in the hospital for over four years until he was transferred last spring to the Atlantis Rehabilitation and Residential Health Care Facility, a private center in Fort Greene, Brooklyn, after the federal government certified him as a “permanent resident under color of law,” essentially acknowledging that he could not be returned to China and qualifying him for medical benefits.
“This gentleman cost us millions of dollars,” said Jeffrey Menkes, the president of New York Downtown. “We try to provide physical, occupational therapy, but this is an acute-care hospital. This patient shouldn’t be here.”
Mr. Yu said that the hospital had treated him well, but that he had made enormous progress in regaining his ability to walk through his rehabilitation regimen at Atlantis. He hopes to return to China when he is well enough to be discharged.
“Here, I am very happy,” he said. “This is very nice — No. 1.”
New York Downtown serves a largely immigrant population, and many patients have no insurance or proof that they are in the United States legally, which is necessary for discharge purposes and eventual reimbursements, said Chui Man Lai, assistant vice president of patient services at the hospital.
**Source: "The New York Times"
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Outside temperatures, sun exposure and gender may trigger glaucoma
Researchers from the Mass. Eye and Ear, Harvard Medical School, Boston, Mass., Department of Medicine, Channing Laboratory, Brigham and Women's Hospital, Boston, Mass., Department of Ophthalmology and Visual Sciences, and University of Michigan, Ann Arbor, Mich., set out to find out how demographic and geographic risk factors are associated with ES. Their study, the "Demographic and Geographic Features of Exfoliation Glaucoma in two United States-Based Prospective Cohorts" is published in the January 2012 issue of Ophthalmology.
Researchers used data from 78,955 women in the Nurses' Health Study (NHS) and 41,191 men in the Health Professionals Follow-up Study (HPFS) residing throughout the continental United States who were prospectively followed for 20 years or more and who provided lifetime residence information to examine the descriptive epidemiologic features of ES or exfoliation glaucoma suspect (EGS).
This study confirmed established associations with age and family history and exfoliation glaucoma or exfoliation glaucoma suspect (EG/EGS), as well as provided new data on associations with gender, eye color and ancestry. "Importantly, those with a lifetime residential history of living in the middle tier and south tier of the United States was associated with 47% and 75% reduced risks, respectively, compared with living in the northern tier, and across the life span, residence at age 15 was the most strongly associated with risk, followed by current residence," the authors wrote.
The study showed an increased risk in females, but it was unclear as if gender-specific differences in the eye, such as axial length differences or environmental factors related to lifestyle, account for why women are more at risk for this disease.
Other findings include:
A positive family history of glaucoma was associated with a more than doubling of risk.
Neither Scandinavian decent nor Southern European ancestry was associated with risk when compared with the larger reference group of mainly other white persons in the study, which indicates that there may be strong environmental factors that may increase risk among populations in Scandinavian countries. Overall the study lacked adequate power to determine whether incidence rates differed by minority groups.
Iris (eye) color did not seem to be a risk factor.
"This large prospective cohort study demonstrates that there is a positive association between latitude and ES risk that is robust and not related to demographic features or other systemic covariates," Dr. Pasquale explained. "Another manuscript we published recently suggests that lower ambient temperature interacts with increased solar exposure to increase the risk of ES. This new work demonstrates a relation between increasing latitude and a condition with a strong predisposition to glaucoma. More work is needed to determine how environmental factors conspire to contribute to ES."
According to the National Eye Institute, ES is the major known cause of open-angle glaucoma, and is one of the leading causes of blindness. With the rapid aging of the U.S. population, the number of individuals affected by the disease will increase to more than three million by 2020.
**Source: Massachusetts Eye and Ear Infirmary
Changes seen in cerebrospinal fluid levels before onset of Alzheimer dementia
Peder Buchhave, M.D., Ph.D, who is affiliated with Lund University and Skane University, Sweden, and colleagues conducted an extended follow-up of the cohort from a previous study of 137 patients with mild cognitive impairment (MCI) at baseline. The median follow-up was 9.2 years.
During the follow-up, 72 patients (53.7 percent) developed AD and 21 (15.7 percent) progressed to other forms of dementia. At the baseline, cerebrospinal fluid Aβ42 levels were reduced and other biomarkers T-tau and P-tau levels were elevated in patients who converted to AD during follow-up compared with levels in patients who did not develop AD.
The study indicates baseline CSF Aβ42 levels were equally reduced in patients with MCI who converted to AD within five years (the early converters) compared to those who converted later between five and 10 years. However, T-tau and P-tau levels were significantly higher in early converters compared to later ones.
Researchers suggest that "approximately 90 percent of patients with MCI and pathologic CSF biomarkers at baseline will develop AD within 9.2 years."
"Therefore, these markers can identify individuals at high risk for future AD least five to 10 years before conversion to dementia. Hopefully, new therapies that can retard or even halt progression of the disease will soon be available. Together with an early and accurate diagnosis, such therapies could be initiated before neuronal degeneration is too widespread and patients are already demented," the authors conclude.
**Source: JAMA and Archives Journals
02 January 2012
El Hospital de Torrevieja emplea la música como terapia para pacientes y familiares
El Hospital de Torrevieja (Alicante) lleva unas semanas acercando a pacientes y familiares la música como terapia y complemento, capaz de hacer más agradable y sosegada la estancia en el Hospital, reduciendo el estrés de los usuarios y mejorando el bienestar de los pacientes y sus familias.
El servicio de diálisis el primero en la utilización de la música en directo como elemento de acompañamiento a la espera de pacientes y familiares en el Hospital de Torrevieja; así, a través de la música clásica y el sonido de guitarras se consiguió un ambiente más confortable y se redujo la sensación de espera de los usuarios. El dueto de música clásica Clasum Desum lleva varios años apostando por la música como elemento complementario al tratamiento de los pacientes. Así, tras experiencias en residencias de Reino Unido han colaborado con el Hospital de Torrevieja.
-Estímulo perfecto
Elisa Isabel Paños Serna, directora de Enfermería del Departamento, se mostró muy satisfecha tras esta primera experiencia, "la música suele ser muy bien recibida por los pacientes quiénes se sienten sorprendidos y relajados al estar en contacto con los acordes de las guitarras, repercutiendo positivamente en su estado anímico y mejorando su sensación de bienestar. Con la música el tiempo pasa más deprisa y ello, en un entorno sanitario, siempre es bien recibido". Según los expertos, la música se perfila como el estímulo perfecto capaz de enriquecer el proceso sensorial y cognitivo del paciente, mejorando los procesos motores y fomentando la disposición al cambio y la creatividad.
La Unidad de Cirugía Sin Ingreso también cuenta con un sistema de relajación a través de la música; los pacientes pueden participar en un programa de relajación que combina una indicaciones de ejercicios de relajación con la música como un elemento altamente positivo que contribuye en la mejora del bienestar de los pacientes, reduciendo su estrés y sensación de ansiedad previa la intervención. Las enfermeras de la Unidad, en colaboración con los profesionales de enfermería del Servicio de Psiquiatría del Centro, son los responsables del diseño y puesta en marcha de un programa de relajación muscular que pretende disminuir la ansiedad de los pacientes en los instantes previos a su intervención, consiguiendo que las condiciones para afrontar la operación sean óptimas y facilitando así el control voluntario de la respiración para que pueda ser mantenida en momentos de ansiedad.
-Navidad a ritmo de música
Siguiendo la apuesta del Departamento por aquellas iniciativas encaminadas a mejorar el estado de ánimo de los usuarios, en las últimas semanas el centro contó con la visita del coro rociero de Torrevieja, así como de un grupo de músicos de la Asociación Española Contra el Cáncer, quiénes de manera altruista llenaron de vida y energía las áreas de consultas externas, Hospital de Día, así como las cafeterías y estancias comunes del centro.
Lanzan un libro sobre la esencia de las Sales de Schussler

Sofia Roca es Diplomada en Naturopatía (Heilpraktiker Institut, 1998), en Homeopatía (Heilpraktiker Institut, 1999). Experta en aplicaciones de Sales de Schüssler. Articulista en revistas especializadas de Homeopatía.
Libro a la venta sólo en la tienda on-line de Laboratorios DHU http://www.dhu.es/ (Edita: Ediciones Semánticas. Primera edición: Octubre 2011. 46 páginas. PVP 20€).
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