Xultophy® (insulin degludec and liraglutide injection) provided superior blood sugar reduction (HbA1c) compared to insulin glargine U-100 (1.94% vs 1.68% respectively; p˂0.0001) when used as an add-on to an SGLT-2i (an oral diabetes medication), according to results from the DUAL IX study presented today at the American Diabetes Association's 78th Scientific Sessions (ADA) in Orlando, US.1
Results from some of the secondary endpoints in DUAL IX included change from baseline in body weight, severe or blood glucose confirmed symptomatic hypoglycaemic events and daily insulin dose at 26 weeks. Mean body weight remained unchanged in the Xultophy® study group versus a 2.0 kg weight gain with insulin glargine U-100. Treatment with Xultophy® demonstrated a 58% lower rate of hypoglycaemia versus insulin glargine U-100 (0.37 events/patient-year of exposure vs 0.90 events/patient-year of exposure respectively; p=0.0035). The average total daily insulin dose was significantly less with Xultophy® than insulin glargine U-100 (36 units per day vs 54 units per day respectively; p˂0.0001).1
"Type 2 diabetes is a progressive disease that often requires treatment intensification," said Dr Athena Philis-Tsimikas, DUAL IX lead investigator and corporate vice president, Scripps Whittier Diabetes Institute. "Xultophy® may be an appropriate treatment option for those adults who are unable to meet their blood sugar goals on their current medication."
Adverse events were similar across both treatment groups; the most common adverse events (≥5%) in the Xultophy® treated patients included viral upper respiratory tract infection, headaches, back pain, increased lipase and nausea. The safety profile of Xultophy® in DUAL IX was consistent with previous Xultophy® clinical trials.1
Additional DUAL IX patient-reported outcomes will be presented on Monday 25 June at ADA:
- Patient-Reported Outcomes for Insulin Degludec/Liraglutide (IDegLira) vs Insulin Glargine (IGlar U-100) as Add-On to Sodium-Glucose Co-Transporter-2 Inhibitor (SGLT2i) ± Oral Antidiabetic Drug (OAD) Therapy in Patients with Type 2 Diabetes: DUAL IX Trial (Poster Presentation 101-LB)